Number of AIM securities in issue as at 28 August 2008: 58,901,312 ordinary shares of 5p (No securities are held as treasury shares). Insofar as the company is aware, as at 28 August 2008 there were 32,740,153 shares not in public hands, representing 55.58% of the issued share capital. At 28 August 2008 the directors had been notified or were otherwise aware of the following holdings of 3% or more of the Company’s issued share capital:

Restriction on transferability of shares

Restrictions on transfer apply to the ordinary shares (the “Shares”) in the capital of Minster which are held by certain shareholders who subscribed for such shares pursuant to the terms of a subscription agreement entered into between Care Capital Investments III LP, Care Capital Offshore Investments III LP, Rho Ventures V, LP and Rho Ventures V Affiliates, LLC (each an “Investor”) and Minster dated 2 March 2007 (the “Subscription Agreement”). 

The restriction is as follows:

As the Shares have not been registered under the US Securities Act of 1933, as amended, (the “Securities Act”) or the securities laws of any state of the United States, they are "restricted securities" within the meaning of Rule 144 under the Securities Act.  For so long as the Shares remain "restricted securities" an Investor may only effect transfers to persons (i) outside the United States pursuant to the offshore resale provisions of Regulation S under the Securities Act; or (ii) within the United States whose assets meet certain sufficiency requirements stated in the Subscription Agreement pursuant to transactions that are both exempt from the registration requirements of the Securities Act and compliant with certain procedures stated in the Subscription Agreement.  Each certificate representing Shares shall bear a legend describing in detail the transfer restrictions applicable to such Shares.